WebCircEIF4G3 destabilizes δ-catenin protein and inactivates β-catenin signaling. (A) TRAP experiment and LC-MS/MS analysis. GST protein expression was detected by western blot. δ-catenin protein... WebFeb 2, 2024 · Renal cell carcinoma (RCC) is one of the top ten tumors over the world. RCC is not sensitive to radiotherapy and chemotherapy. Therefore, it is necessary to find new targets for the treatment. CircRNAs are a special type of noncoding RNAs, which play important roles in many types of cancer. In this study, we found circ_000558 was …
Circ-EIF4G3 promotes the development of gastric cancer …
WebCircEIF4G3 destabilizes δ-catenin protein by enhancing TRIM25-mediated ubiquitin degradation and functions as a miRNA sponge to modulate miR-4449/SIK1 axis, which synergistically leads to the ... WebNov 16, 2024 · Overexpressing SRRM4, known for regulating ME inclusion in mRNAs critical for neural differentiation, in human HEK293 cells resulted in the biogenesis of over 2000 novel ME-circRNAs, including ME-circEIF4G3, and changes in the abundance of many canonical circRNAs, including circSETDB2 and circLRBA. This shows SRRM4, in … church chatter
Circular RNA EIF4G3 suppresses gastric cancer progression …
WebAug 10, 2024 · The formation of a unique back-splice junction (BSJ) differentiates the circRNAs from their linear counterpart. CircRNAs are highly expressed in the central nervous system where many of them are regulated during development 1 – 3, inflammation 4, and also found to function as biomarkers in cancer 5 – 7. Webhsa_circEIF4G3_060. Last modified by: XXH Created Date: 4/29/2024 8:53:00 AM Other titles: 交集的circRNA Sheet2 ... WebAug 26, 2024 · CircEIF4G3 is expected to be a biomarker and therapeutic target for predicting the prognosis of gastric cancer. By analyzing the Master Gene Expression (GEO) dataset, we identified circRNAs that are differentially expressed in GCs. The researchers explored the biological role of circRNAs in GC through in vitro functional analysis and in … church chat snl