Cisplatin hydrolysis
WebDec 19, 2024 · The hydrolysis rate of cisplatin and transplatin affects their reactivity with biomolecules. ... USA). The antioxidant 2-mercaptoethanol was purchased from Wako Pure Chemical Industries (Osaka, Japan). Cisplatin was synthesized according to a previous report . Transplatin was purchased from Sigma Aldrich (Saint Louis, MO, USA). Other … http://www.electrochemsci.org/papers/vol12/121211316.pdf
Cisplatin hydrolysis
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WebMay 1, 2024 · Abstract. The discovery of the antitumor activity of cisplatin in 1969 has accelerated research in platinum chemistry. In particular, cisplatin hydrolysis, the rate-determining process activating ... WebApr 11, 2024 · Cisplatin (CISPt) III: Systemic: Lipid coated [email protected] increased the transdermic drug administration. Lipid coating avoided the toxic accumulation of CISPt in other organs, highly reducing its systemic toxicity: Tu et al. Ovalbumin (OVA) IV: Systemic
WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6 WebThe anticancer drug cisplatin hydrolyzes in water with a rate constant of 1.5 × 10 −3 min −1 at pH 7.0 and 25°C. Calculate the half-life for the hydrolysis reaction under these conditions. Calculate the half-life for the hydrolysis reaction under these conditions.
WebCisplatin undergoes hydrolysis in water. The chloride concentration is an important factor in determining the hydrolysis or aquation of cisplatin. The high chloride concentration ( ∼ 103 mM) of blood plasma prevents the hydrolysis of cisplatin. WebDownstream reaction of cisplatin with methionine-containing peptides: pH-dependent competition between hydrolytic cleavage and macrochelation. Inorganica Chim Acta.. 2009-02; 362(3):953-966. O Hohage, S Manka, WS Sheldrick. Lehrstuhl fÜr Analytische Chemie der Ruhr-Universität Bochum, D-44780 Bochum, Germany.
WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In …
WebChemical basis for the detoxification of cisplatin-derived hydrolysis products by sodium thiosulfate Cisplatin remains the most widely used platinum-based anti-cancer drug and is included on the World Health Organization's list of essential medicines. how has south europe contributed to the artsWebJan 11, 2024 · Cisplatin is a squared planar platinum (II) complex composed by a central metal atom coordinated with two chlorides and two ammonia molecules in a cis configuration (Figure 2 ). Even though the … how has software benifited the business worldWebJun 1, 2015 · For obtaining stable solution of cisplatin sample containing 10 ng Pt/mL was prepared from the stock cisplatin solution in 0.9% NaCl, and injected onto the column immediately after the dilution. To identify monoaquacisplatin, which is the first hydrolysis product of cisplatin, the same solution was also injected 15 min how has south africa changed after apartheidWebOct 10, 2002 · Cisplatin ( cis -DDP) is subject to nucleophilic displacement of chloride in water, forming aquated species, subsequently liberating hydrogen ion (s) with increasing pH. This study intends to theoretically analyze the hydrolysis and polyprotic dissociation behavior of -DDP in various aqueous media. highest rated pedicure in burnsville mnWebKinetics of the adduct formation of cisplatin and its hydrolysis products with 5′-GMP was investigated using capillary electrophoresis (CE) under ‘simulated physiological conditions’. Therefore, chloride ion and phosphate concentration as well as the pH were chosen comparable to intracellular conditions. highest rated pediatric stethoscopeWebcis-Dichlorodiammineplatinum(II). Acid Hydrolysis and Isotopic Exchange of the Chloride Ligands1 John W. Reishus and Don S. Martin Jr. Cite this: J. Am. Chem. Soc.1961, 83, 11, 2457–2462 Publication Date(Print):June 1, 1961 Publication History Publishedonline1 May 2002 Publishedinissue1 June 1961 … how has society changed since covidWebactivity of cisplatin. Aqua complexes [PtX(NH 3) 2(H 2O)] + (X ¼Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis- and trans-[PtX(NH 3) 2(H 2O)] +, have been allowed to react with highest rated pencil sharpener