Dynein light intermediate chain binding
Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components … WebIn both complexes, the heavy chain (HC) subunits hydrolyze ATP and interact with microtubules to generate force. The N-termini of the dynein HCs act as scaffolds for the accessory proteins, which include the dynein intermediate chain (IC), the dynein light-intermediate chains (LICs), and the dynein light chains (LCs) [1].
Dynein light intermediate chain binding
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WebJun 5, 2024 · Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150 Glued and nuclear distribution … WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated …
Web1 day ago · Additionally, to the HC, there are several light and intermediate chains present in the ODA and IDA, alongside with light-intermediate chains for the IDA. ... Step 2: The β-HC, from helical bundle 5 to the β-dynein head, shifts slightly. The two binding partners LC3 and the α kelch domain move with the β-tail. Step 3: The stalk and MTBD of ... WebMay 1, 2024 · Presumably to accommodate its very broad range of activities, a variety of dynein “cargo”-binding mechanisms have evolved. In some cases, dynein-cargo associations are mediated directly by the cytoplasmic dynein intermediate or light intermediate chain subunits [[2], [3], [4]].
WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem. 2005; 280:8172–8179. [Google Scholar] Lo KW, Naisbitt S, Fan JS, Sheng M, … WebThe dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in vitro motility assays and living tissue culture cells. Importantly, we will also investigate the role of
WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate …
WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. fnaf security breach vanessa x male readerEach molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… fnaf security breach vanessa x readerWebMar 4, 2024 · The cytoplasmic dynein light intermediate chains (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood. Here, we used in utero electroporation of shRNAs or LIC functional domains to determine the relative contributions of the two LICs in the developing rat brain. greensville county government buildingWebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690 … greensville county courtWebAug 30, 2024 · Further, we noticed that the N-terminus of kazrin C shares homology with dynein/dynactin adaptors and that it directly interacts with the dynactin complex and the dynein Light Intermediate Chain 1 (LIC1). Altogether, the data indicate that one of the primary kazrin functions is to facilitate endocytic recycling via the perinuclear endocytic ... fnaf security breach vanny artWebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing. greensville correctional center wardenfnaf security breach vanny thicc