WebThrough tackling the question of how epigenetic mechanisms coordinate postnatal heart maturation and terminally differentiated cardiomyocytes homeostasis, we have revealed … http://aibinlab.org/publication/
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WebAibin He . Email: ahe(at)pku ... Research Area: The He lab has a long-standing interest in principles in controlling cell fate decisions and coordinating cell behaviors for mammalian organ formation, and cardiovascular diseases and regeneration To achieve these goals, we have developed a number of novel technologies, including single-cell ChIP ... WebOur research addresses the fundamental questions: how normal cells respond to environmental carcinogens and evolve into cancerous cells. In particular, our group …
WebHaiqing Xiong. Chen C. Li. [...] Aibin He. Single-cell measurement of chromatin states, including histone modifications and non-histone protein binding, remains challenging. We present a low-cost ... http://aibinlab.org/project/
WebOct 3, 2024 · An efficient, generalizable method for genome-wide mapping of single-cell histone modifications or chromatin-binding proteins is lacking. Here, we develop CoBATCH, combinatorial barcoding and targeted chromatin release, for single-cell profiling of genomic distribution of chromatin-binding proteins in cell culture and tissue. WebAibin He Endothelial cells (ECs) across ages and tissues are highly heterogeneous in developmental origins, structures, functions, and cellular plasticity. Here, we applied …
WebOct 3, 2024 · Here, we develop CoBATCH, combinatorial barcoding and targeted chromatin release, for single-cell profiling of genomic distribution of chromatin-binding proteins in …
WebMay 13, 2024 · To gain insights into cellular plasticity of ECs, we identified bivalent chromatin occupancy of otherwise mutually exclusive EC- (ERG) and mesenchymal-specific (TWIST1/SNAI1) transcription factors promoting endothelial-to-mesenchymal transition. blasonnassiezWebhe/him/his. Biography. Dr. Michal Aibin is a visiting associate teaching professor of computer science at the Khoury College of Computer Sciences at Northeastern University’s Vancouver campus. Outside of his role at Northeastern, he is also a research faculty member at the British Columbia Institute of Technology. His research interests ... blastoise levelWebJan 1, 2012 · Authors Aibin He 1 , Xiaohua Shen , Qing Ma , Jingjing Cao , Alexander von Gise , Pingzhu Zhou , Gang Wang , Victor E Marquez , Stuart H Orkin , William T Pu Affiliation 1 Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. PMID: 22215809 PMCID: PMC3258964 DOI: … blastoise 2 102WebIn particular, our group focuses on the role of epitranscriptomics, epigenetics, and autophagy in regulating genomic integrity and cellular homeostasis and to investigate their impact on cancer development and therapeutic resistance, with an emphasis on skin cancer including squamous cancer and melanoma. hugh perkins ageWebDeciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH, a combinatorial barcoding method allowing high-throughput single-cell joint detection of chromatin occupancy and tr … hugh padghamWebWe also present RNA-sequencing data demonstrating that HE cells in different anatomic sites, which produce hematopoietic progenitors with dissimilar differentiation potentials, are molecularly distinct. Hemogenic and non-HE cells in the yolk sac are more closely related to each other than either is to hemogenic or non-HE cells in the major ... hugh putnamWebSep 24, 2014 · Aibin He 1 , Fei Gu 2 , Yong Hu 2 , Qing Ma 2 , Lillian Yi Ye 2 , Jennifer A Akiyama 3 , Axel Visel 4 , Len A Pennacchio 5 , William T Pu 6 Affiliations 1 1] Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA [2] Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences ... blast joints oilfield